ANTI-AGING BLEND - MixTrac™ Skin Renewal C LC

Introduction to the Anti-Aging Blend

MixTrac™ Skin Renewal C LC is an advanced blend of skincare actives combining Bakuchiol and Niacinamide, designed to improve skin texture, support the skin barrier, and enhance skin tolerance to bioactive ingredients. The formulation leverages on the complementary mechanisms of these two scientifically supported actives, incorporating a solvent and solubilizer system to improve their stability and dispersibility in cosmetic formulations.

Bakuchiol is derived from the seeds and leaves of Psoralea corylifolia L. (synonym: Cullen corylifolium). It is known for its retinol-like activity and better skin tolerability. Studies suggest that Bakuchiol can regulate the expression of genes involved in epidermal renewal and extracellular matrix protein synthesis, helping improve skin smoothness, elasticity, and visible signs of aging. It also exhibits antioxidant and anti-inflammatory properties, helping protect the skin against oxidative stress and premature aging [1][3].

Niacinamide (Vitamin B3) is a multifunctional active ingredient shown to increase the synthesis of ceramides and other epidermal lipids. This helps strengthen the skin barrier, reduce transepidermal water loss, and improve skin dryness and impaired barrier function. Niacinamide also helps soothe the skin, improve pigmentation, and promote a more even skin tone, contributing to better skin tolerance to formulations containing active ingredients [2].

The combination of Bakuchiol and Niacinamide in MixTrac™ Skin Renewal C LC provides complementary benefits: Bakuchiol supports skin renewal and structural improvement, while Niacinamide helps strengthen the protective barrier and maintain favorable physiological conditions for the skin.

In addition to these two key actives, MixTrac™ Skin Renewal C LC contains 1,2-Isopropylideneglycerol, PEG-7 Glyceryl Cocoate, and 1,2-Hexanediol, which serve as solvents, solubilizers, and preservation boosters. These ingredients help improve the stability of the active system and facilitate its incorporation into serums, lotions, gels, and moisturizing creams. Combining efficacy with gentleness, MixTrac™ Skin Renewal C LC is suitable for developing cosmetic products positioned as alternatives to retinol, with a focus on improving skin texture, promoting an even complexion, and maintaining healthy skin.

Key Benefits

Anti-Aging and Wrinkle Reduction

Bakuchiol stimulates the expression of genes involved in collagen, elastin, and extracellular matrix synthesis, helping reduce the appearance of wrinkles and improve skin elasticity and firmness. Clinical research has demonstrated anti-aging efficacy comparable to retinol, with less irritation [1]. Bakuchiol also acts on multiple biological mechanisms involved in skin aging, including increasing collagen and fibronectin synthesis and reducing the activity of collagen-degrading enzymes [3].

Antioxidant Protection

Bakuchiol helps neutralize free radicals, reduce oxidative stress, and protect cells against environmental factors that contribute to skin aging. As a precursor to NAD⁺, Niacinamide supports cellular energy metabolism, contributing to the skin’s antioxidant defenses [2][3][4].

Anti-Inflammatory and Soothing Benefits

Bakuchiol helps regulate pro-inflammatory mediators, including PGE2 and MIF, and reduce inflammatory responses triggered by UV exposure or oxidative stress [3][4]. Niacinamide also helps reduce inflammation, improve the condition of sensitive skin, and support skin recovery following irritation [2].

Strengthening the Skin Barrier

Niacinamide stimulates the synthesis of ceramides, cholesterol, and free fatty acids in the stratum corneum, helping improve skin hydration and barrier function [2].

Brightening and Evening Skin Tone

Bakuchiol has been reported to help improve hyperpigmentation through its anti-inflammatory and antioxidant effects and its ability to promote epidermal renewal [1]. Niacinamide can also inhibit melanosome transfer from melanocytes to keratinocytes, helping reduce hyperpigmentation and improve uneven skin tone [2].

Cosmetic Applications

MixTrac™ Skin Renewal C LC is commonly incorporated into:

• Serums
• Moisturizing creams
• Lotions
• Facial cleansers
• Body washes

References

[1] Chaudhuri, R., & Bojanowski, K. (2014). Bakuchiol: A Retinol-Like Functional Compound Revealed by Gene Expression Profiling and Clinically Proven to Have Anti-Aging Effects. International Journal of Cosmetic Science, 36(3), 221–230.

[2] Boo, Y. C. (2021). Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation. Antioxidants (Basel, Switzerland), 10(8), 1315.

[3] Bluemke, A., Ring, A. P., Immeyer, J., Hoff, A., Eisenberg, T., Gerwat, W., Meyer, F., Breitkreutz, S., Klinger, L. M., Brandner, J. M., Sandig, G., Seifert, M., Segger, D., Rippke, F., & Schweiger, D. (2022). Multidirectional activity of bakuchiol against cellular mechanisms of facial ageing – Experimental evidence for a holistic treatment approach. International Journal of Cosmetic Science, 44(3), 377–393.

[4] Nizam, N. N., Mahmud, S., Ark, S. M. A., Kamruzzaman, M., & Hasan, M. K. (2023). Bakuchiol, a natural constituent and its pharmacological benefits. F1000Research, 12, 29.